Bmi, Pcos and Relationship of Androgen Excess in Indian Ethnic Group of Patients

Dr. Roya Rozati MD Dr. Roya Rozati MD, Dr. Mohd Ashraf Ganie, Dr. Imtiyaz Wani, Dr. Humaira Minhaj, Wajeeda Tabasum M. Sc, Taalia Nazeer Ahmed, Dr. Mohammed Sarosh Ahmed, Ayapati Mehdi Gautam, Dr. Vikram Aiman Ayapati

Abstract


Background: Polycystic ovary syndrome (PCOS) is the most common endocrine condition in reproductive-age women. By comprising reproductive, endocrine, metabolic and psychological features—the cause of PCOS is still unknown. As of now, there is no cure, and management which is persistently suboptimal as it depends on the ad hoc management of symptoms only. Various Research Studies have recently revealed that androgens have an important role in regulating female fertility. Biochemical or clinical profile of hyperandrogenism is important elements of polycystic ovary syndrome (PCOS). Androgen excess is a defining feature of polycystic ovary syndrome (PCOS), which affects 10% of women and represents a lifelong metabolic disorder, with increased risk of type 2 diabetes, hypertension, Insulin resistance and cardiovascular events. In women, the increases in androgens are associated with increases in inflammatory cytokines, and reducing androgens reduces inflammation. The aim of this study was to investigate the complex symptoms of Androgen Excess and the correlations in patients with PCOS from an outpatient reproductive medicine clinic in South India. Methods and Findings: We conducted a case control study of 140 PCOS patients and 558 controls to evaluate the Anthropometric measurements were recorded, differences in body mass index (BMI), total testosterone (TT), modified Ferriman–Gallwey hirsutism score, sex hormone binding globulin (SHBG), and free androgen index (FAI) between PCOS patients and controls. Results: DHEAS was significantly higher in the PCOS (p < 0.01) compared to controls. All androgen parameters were significantly lower and sex hormone binding globulin (SHBG) significantly lower in PCOS (p < 0.01) compared to controls. A combination of SHBG, clinical and biochemical hyperandrogenism and menstrual irregularities may be considered as diagnostic markers of PCOS in adolescents and for the identification of a ‘risk group’ for developing PCOS.Androgen excess plays a prominent role in the development of metabolic disturbances associated with PCOS, with a discernible impact

Keywords


Androgen Excess, PCOS, body mass index (BMI), sex hormone binding globulin (SHBG).

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