Development of the Experimental Model of Infected Pancronecrosis

M.Sh. Khakimov, B.B. Fayzullaev, Zh.R. Asatullaev, M.B. Bozorboev, M.Kh. Muhammadiev

Abstract


On 12 experimental animal (dogs) in 3 series on model working out local infected pancreonecrosis with use of the allocated cultures pseudomonas aeruginosa, E. coli, staph. aureus researches are carried out in concentration 103, 104, 105 colony forming unit/ml. As a result of the spent researches the model local infected pancreonecrosis which consists in introduction in area of a body of a pancreas in three points in diameter to 1,0 sm on 0,5 ml of a microbic suspension on concentration 104 colony forming unit/ml on depth nearby 0,5 sm. Experimental efficiency of model see has made 100 % that has been proved macro- and microscopic researches

Keywords


pancreonecrosis, cultures, microbic suspension, microscopy, systemic inflammatory

Full Text:

PDF

References


Boyko, V.V., Krivoruchko, I.A., Shevchenko, R.S., Smachilo, R.M. and Pesotsky, O.N. “Acute pancreatitis: pathophysiology and treatment.” Kharkov: Tornado (2002): 288.

Viskunov, V.G., Feshchenko, A.M., Svet-lana, I.P., Barabanov, I.E., Marina, A.S. and Pupyshev, A.B. “The use of sandostatin in pancreatic necrosis (pilot study).” Annals of Surgical Hepatology 12.2 (2007): 52-56.

Vishnyakov, S.S. “Reamberin in preventing the transformation of the edematous form of acute pancreatitis into necrotic (experimental study).” dis. cand. honey. Nauk, Ulyanovsk (2008): 25.

Ershov, A.V. “Pathogenetic factors in the development of cardiovascular insufficiency in pancreatic necrosis.” dis. cand. honey. Nauk, Omsk (2007): 21.

Michurin, V.F. “Experimental model of traumatic pancreatitis in rats // In the collection of materials of the conference “Actual issues of general and emergency surgery.” Kyiv (1971): 181-183.

Morozov, S.V., Poluektov, V.L., Dolgikh, V.T. and Reis, B.A. “Ultrasound model of acute pancreatitis.” Bulletin of Experimental Biology and Medicine 140.12 (2005): 705-706.Khakimov, M.S. “Ways to improve the diagnosis and treatment of acute pancreatitis.” dis. doctor of medical sciences Tashkent (2006): 38.

Shapovalyants, S.G., Andrey, G.M. and Pankov, A.G. "Surgical interventions in acute destructive pancreatitis." Annals of Surgical Hepatology 15.2 (2010): 58-66.

Shimunov, G.Y. “Features of changes in metabolic processes in the blood, liver and myocardium at different stages of acute experimental pancreatitis and their correction.” dis. cand. honey. Sciences. Rostov-on-Don (2006): 18.

Shchetinin, N.A. “Morphofunctional ra-tionale for the use of high doses of ascorbic acid in the treatment of experimental acute pancreatitis.” dis. cand. honey. Nauk, Orenburg (2010): 24.


Refbacks

  • There are currently no refbacks.


Copyright (c) 2022 Annals of Pharma Research

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.